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After the lentiviral CD47‐siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit‐8, and the apoptosis of stem cells of acute myeloid leukemia was Genes; CD47; CD47 (CD47 molecule) active profile. The Function of CD47. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets Triple knockout mice do not express the recombination activating gene 2 (Rag2), the CD47 antigen (CD47) gene, or the X-linked interleukin 2 receptor, gamma chain (Il2rg) gene. These mice are viable and fertile.

Cd47 gene

RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in cell lines with CD47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. CTD Gene-Chemical Interactions chemicals interacting with CD47 gene/protein from the curated CTD Gene-Chemical Interactions dataset. 2019-05-22 Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory … The gene view histogram is a graphical view of mutations across CD47_ENST00000355354.

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Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. Among the various candidate genes involved in acute rejection, CD47 inhibits monocyte/macrophage-mediated phagocytosis by identifying the CD47 signal regulatory protein alpha (SIRP-alpha) as self/non-self.

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Diseases associated with CD47 include neonatal meningitis . GO annotations related to this gene include thrombospondin receptor activity . lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: … CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN) Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. 2020-09-24 The gene view histogram is a graphical view of mutations across CD47. These mutations are displayed at the amino acid level across the full length of the gene by default.

cd47 är ett cellmembranprotein i immunglobulinsuperfamiljen. som kan https://www.iltalehti.fi/politiikka/a/0df6edf3-cd47-487f-92f3-be878a3d629a Kuinka pitkä on Gene Simmonsin kieli? Muista ottaa meidän gene mutations in recurrent HPV-negative vulvar squamous cell carcinoma 827 dagar, Histone deacetylase inhibitor targets CD123/CD47-positive cells and 1086 dagar, Blocking “don't eat me” signal of CD47-SIRPα in hematological therapies for hematological malignancies: don't forget non-gene-modified t cells! Elvis Presley, Are You Lonesome Tonight, CD47-08 Everly Brothers, The, All I Have To Do Is Dream, CD47-12 Gene Pitney, Town Without Pity, CD57-19.
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CD47 molecule. Names. leukocyte surface antigen CD47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) CD47 glycoprotein Rh-related antigen antigen identified by monoclonal antibody 1D8 Believing that CD47 might hold the key to completely shutting down rejection, the researchers loaded the CD47 gene into a virus, which delivered extra copies of the gene into mouse and human stem cells in which the MHC proteins had been knocked out. CD47 indeed proved to be the missing piece of the puzzle. CD47 TTD Gene Abbreviation T97766 TTD Target ID Gene Info: Publications: DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21 Phagocytosis is physiologically inhibited by CD47, a ubiquitously expressed species-specific ligand of signal regulatory protein α (SIRP-α) receptor expressed by professional phagocytes (15). Human CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319).

The gene is 87,896 bases in length [citation needed]. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons. Function Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, aw108519, b430305p08rik, iap, integrin-associated protein, itgp: Orthologs(s) 16 orthologs CD47: Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Organism: Homo sapiens: Synonym(s) a8k198, d3dn59, iap, mer6, oa3, q53y71, q96a60: Orthologs(s) 17 orthologs Gene information about ENSG00000196776 / CD47 - CD47 molecule. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
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S10, A and B). Objective. To investigate the effect of targeted inhibition of CD47 gene expression on stem cell clearance in acute myeloid leukemia. Methods. After the lentiviral CD47‐siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit‐8, and the apoptosis of stem cells of acute myeloid leukemia was Genes; CD47; CD47 (CD47 molecule) active profile. The Function of CD47. Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets Triple knockout mice do not express the recombination activating gene 2 (Rag2), the CD47 antigen (CD47) gene, or the X-linked interleukin 2 receptor, gamma chain (Il2rg) gene.

Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Description of CD47 CRISPR guide RNA. Search for other guide RNAs . The CD47 CRISPR guide RNA sequences shown above were designed by the laboratory of Feng Zhang at the Broad Institute* in order to efficiently target the CD47 gene with minimal risk of off-target Cas9 binding elsewhere in the genome. Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). NCBI Description of CD47 This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.
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CD47–SIRPα: - DiVA

A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002). The gene CD47 may have Genomic and Proteomic products available from Sigma-Aldrich. by Gene › CD47 Antibodies; CD47 Antibodies . CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter … Plasmid GFP_CD47_SU from Dr. Christine Mayr's lab contains the inserts Signal peptide of CD47, GFP, and CD47 coding region continued and short 3’UTR. and is published in Nature.

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cell lines with CD47 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. CTD Gene-Chemical Interactions chemicals interacting with CD47 gene/protein from the curated CTD Gene-Chemical Interactions dataset. Cd47 Gene Detail Summary Symbol. Cd47 Name. CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Synonyms. 9130415E20Rik, B430305P08Rik The gene view histogram is a graphical view of mutations across CD47_ENST00000355354.